Poor antibacterial effect of ropivacaine: comparison with bupivacaine.
نویسندگان
چکیده
ROPIVACAINE (1-propyl-29,69-pipecoloxylidide) is a long-acting aminoamide local anesthetic that has been introduced into clinical use in the last few years, largely as a replacement for bupivacaine. Bupivacaine has been reported to possess a significant antibacterial effect. Because data regarding ropivacaine are not available, we compared the antibacterial effects of clinically appropriate concentrations of ropivacaine and bupivacaine in a laboratory setting.
منابع مشابه
Comparison of the Effect of Intrathecal Bupivacaine with Intrathecal Ropivacaine on Hemodynamic of Patients under Elective Caesarean Section
Background and Objectives: The correct management of delivery and anesthesia hs important for maternal and fetal health outcome during cesarean section. The aim of this study was to compare the effect os spinal anesthesia with bupivacaine and ropivacaine on the hemodynamic parameters of pregnant women during cesarean section. Methods: This study was a randomized double blinded clinical trial o...
متن کاملComparative ventricular electrophysiologic effect of racemic bupivacaine, levobupivacaine, and ropivacaine on the isolated rabbit heart.
BACKGROUND Numerous local anesthetics have an asymmetric tetrahedron carbon, which confers stereoselective differences between the isomers. The authors attempted to quantify the depressant effect of racemic bupivacaine, levobupivacaine, and ropivacaine on myocardial ventricular conduction and on myocardial contractility. METHODS The authors studied the pharmacokinetics (outflow concentration)...
متن کاملA double-blind comparison of 0.25% ropivacaine and 0.25% bupivacaine for extradural analgesia in labour.
Ropivacaine is a new aminoamide local anaesthetic. Compared with bupivacaine, ropivacaine possesses a higher threshold for systemic toxicity and a high selectivity for sensory fibres. We have compared prospectively these two agents in a concentration of 0.25% for extradural analgesia in labour. A total of 104 parturients requesting extradural analgesia were randomized to receive either ropivaca...
متن کاملEffect of dexamethasone on the duration of interscalene nerve blocks with ropivacaine or bupivacaine.
BACKGROUND Pain after shoulder surgery is often treated with interscalene nerve blocks. Single-injection blocks are effective, but time-limited. Adjuncts such as dexamethasone may help. We thus tested the hypothesis that adding dexamethasone significantly prolongs the duration of ropivacaine and bupivacaine analgesia and that the magnitude of the effect differs among the two local anaesthetics....
متن کاملPharmacokinetics of three doses of epidural ropivacaine during hysterectomy and comparison with bupivacaine.
PURPOSE Ropivacaine is a new long-acting aminoamide local anaesthetic, structurally related to bupivacaine. The clinical efficacy of 125 mg, 187.5 mg and 250 mg ropivacaine have been reported and compared with 125 mg bupivacaine for epidural analgesia during hysterectomy. In the pharmacokinetic part of this study the objectives were to 1) determine the dose proportionality in the pharmacokineti...
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ورودعنوان ژورنال:
- Anesthesiology
دوره 91 3 شماره
صفحات -
تاریخ انتشار 1999